Quinolines and derivatives
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Filtered Search Results
Medchemexpress LLC IL-31 Cynomolgus H 2ug | 2ug
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IL-31 is a multifunctional cytokine that activates STAT3 through IL-31 heterodimeric receptors (IL31RA and OSMR) and may activate STAT1 and STAT5 IL-31 is known for its involvement in skin immunity where it regulates immune responses IL-31 Protein Cynomolgus (HEK293 His) is the recombinant cynomolgus-derived IL-31 protein expressed by HEK293 with C-His labeled tag
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Sigma Aldrich Fine Chemicals Biosciences 1,1'-Diethyl-2,2'-carbocyanine iodide 97% | 605-91-4 | MFCD00011975 | 250MG
1,1'-Diethyl-2,2'-carbocyanine iodide 97% | Purity: 97% | Mol Wt: 480.38 | 605-91-4 | MFCD00011975 | 250MG
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Medchemexpress LLC STF-31 | 724741-75-7 | 99.8% | 423.53 | 5 MG
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STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC50 of 1 μM. It is also a NAMPT inhibitor and inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells.
- Selective inhibitor of glucose transporter 1 (GLUT1).
- NAMPT inhibitor.
- Inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells.
- Specifically toxic to RCC4 cells at concentrations of 0.01-10 μM, while RCC4/VHL cells are relatively unaffected.
- Causes necrotic cell death and does not induce autophagy, apoptosis, or DNA damage at concentrations of 1.25-5 μM for 3 days.
- Reduces light-induced CX3CR1gfp/+ mice microglial activation and retinal degeneration in vivo at 10 mg/kg.
- Promotes accumulation of necrotic thymocytes after Dexamethasone-induced apoptosis in vivo at 10 mg/kg.
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Medchemexpress LLC 5'-O-(4,4'-Dimethoxytrityl)-5-methoxyuridine | 2095417-73-3 | C31H32N2O9 | 25 MG
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5'-O-(4,4'-Dimethoxytrityl)-5-methoxyuridine is a purine nucleoside analog. Purine nucleoside analogs exhibit broad antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve inhibition of DNA synthesis and induction of apoptosis.
- Purine nucleoside analog
- Broad antitumor activity
- Targets indolent lymphoid malignancies
- Inhibits DNA synthesis
- Induces apoptosis
- Relevant for cancer research
- Related to oligonucleotides and nucleoside analogs
- Applicable to various cancers
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Medchemexpress LLC 1,4-Benzenediamine, N1-(1,4-dimethylpentyl)-N4-phenyl- | 3081-01-4 | 98.3% | 282.42 | 10 G
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7-PPD (DMPPD) is a rubber antioxidant that scavenges free radicals and inhibits the oxidative degradation of rubber chains. It shows promise for research in tire manufacturing and rubber product processing. It is for research use only and not sold to patients.
- Acts as a rubber antioxidant
- Scavenges free radicals
- Inhibits oxidative degradation of rubber chains
- Shows potential for research in tire manufacturing
- Shows potential for research in rubber product processing
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Medchemexpress LLC PARP1-IN-31 | 5MG
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PARP1-IN-31 | 5MG
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eMolecules 4-Chloro-6,7-difluoro-quinoline-3-carbonitrile | 886362-75-0 | MFCD06796586 | 25g
Combi-Blocks | 4-Chloro-6,7-difluoro-quinoline-3-carbonitrile | 25g | 448004410 | OR-6955 | 98.000 | 886362-75-0 | MFCD06796586 | 224.590 | C10H3ClF2N2
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Ambeed 5Nitroisoindoline1 3dione
5-Nitroisoindoline-1,3-dione, 89-40-7, 97%
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![Medchemexpress LLC Pyrimido[4,5-d]pyrimidinone derivative (1-cyclobutyl, 2,6-dimethylphenyl, 2-methoxy-4-piperazinyl) | 2172617-15-9 | 99.8% | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000232299.png-250.jpg)
Medchemexpress LLC Pyrimido[4,5-d]pyrimidinone derivative (1-cyclobutyl, 2,6-dimethylphenyl, 2-methoxy-4-piperazinyl) | 2172617-15-9 | 99.8% | 100 MG
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YKL-06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor for research use. It displays low-nanomolar activity against SIK isoforms and is supplied as a purified small-molecule reagent.
- Potent SIK inhibition (SIK1 = 6.56 nM, SIK2 = 1.77 nM, SIK3 = 20.5 nM).
- High reported purity (approximately 99.8% by HPLC).
- Molecular formula C30H37N7O2; molecular weight 527.66 g/mol.
- Available in multiple sizes and formats, including milligram quantities and a 10 mM solution in DMSO.
- For research use only; not for human or veterinary applications.
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Ambeed R 5 S 1 2Dihydroxyethyl 3 4d
(R)-5-((S)-1,2-Dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one, 50-81-7, 98%
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Ambeed 4 4 Bipyridine
4,4'-Bipyridine, 553-26-4, 98%
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Medchemexpress LLC MYF-03-176 | 2857937-59-6 | 99.72% | 410.37 | 25 MG
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MYF-03-176 is an orally active inhibitor of TEAD, suppressing TEAD transcriptional activity with an IC50 of 11 nM. It inhibits hippo signaling defective malignant pleural mesothelioma (MPM) cells and demonstrates strong antitumor efficacy in an MPM mouse xenograft model. The IC50 values for TEAD1, TEAD3, and TEAD4 are 47, 32, and 71 nM, respectively.
- Orally active inhibitor of TEAD
- Suppresses TEAD transcriptional activity with an IC50 of 11 nM
- Inhibits hippo signaling defective malignant pleural mesothelioma (MPM) cells
- Demonstrates strong antitumor efficacy in MPM mouse xenograft model
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Medchemexpress LLC Sri 6409-94 | 127697-58-9 | 99.3% | 379.49 | 25 MG
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SRI 6409-94 is an orally active Ro 13-6298 analogue that is teratogenic. It serves as a molecular tool to study the effect of the three-dimensional configuration of retinol on teratogenic activity.
- Orally active Ro 13-6298 analogue
- Teratogenic
- Molecular tool for studying retinol's three-dimensional configuration and teratogenic activity
- Causes deformed offspring in a dose-dependent manner in virgin female outbred Syrian golden hamsters
- Leads to significant reductions in mean fetal body weight and in the numbers of ossified skeletal districts
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Medchemexpress LLC PVD-06 | 3032975-48-4 | 98.3% | 1074.13 | 25 MG
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PVD-06 is a selective PROTAC PTPN2 degrader with a DC50 of 217 nM (selectivity index >60-fold over PTP1B). It induces PTPN2 degradation via a VHL-, ubiquitin, and proteasome-dependent pathway. PVD-06 can promote T cell activation and amplify IFN-γ-mediated anticancer activity. It can be used to further investigate PTPN2 in diseases such as leukemia and melanoma.
- Induces PTPN2 degradation
- Reduces PTPN2 protein levels
- Enhances phosphorylation of STAT1 in Jurkat cells
- Promotes T cell proliferation under CD3/CD28 stimulation
- Amplifies B16F10 cell growth inhibition in the presence of IFN-γ
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Ambeed Methyl 5bromo2fluorobenzoate
Methyl 5-bromo-2-fluorobenzoate, 57381-59-6, 98%
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